Stéphane VELLAY, PharmD
London UK
Career objective
Keywords:
Summary of qualifications
- 5 years experience in pharmaceutical and software industries for drug discovery & development
- Expert in life science: chemistry, biology, drug absorption distribution metabolism and elimination (ADME), imaging, virtual screening
- Conversant with computational modelling & simulation, scientific programming
- Lead by example, excellent interpersonal communication skills, promote team work across different disciplines, build trust relationship
- Native French speaker, fluent in English, intermediate in German
Work Experience
from 2007
Senior Application Scientist
Accelrys, Client Solutions Department EMEA, Cambridge UK (E Vande Water)
Grow usage of Pipeline Pilot (scientific workflow technology) in the scientific community by identifying users' needs and advising or developing appropriate solutions, via various ways:
- Demonstration: Explaining benefits to users, and developing tailored proof-of-concept, each week in a different scientific environment or company;
- Training: Leading by example, provided more than a hundred training, with excellent feedback from both new and expert users, about most of the component collections;
- Support: Became a trusted advisor (inside and outside company) in a variety of Pipeline Pilot component collections (esp. Imaging, Reporting, Text Analytics) and in data visualization;
- Consulting Services: Engaged in various projects for scientific expertise (e.g. imaging, PKPD, computational chemistry) or interface usability.
Initiated and developed projects recognized and reused by the community or my team:
- The creation of the Bibliography Platform led to a publication and the wide promotion of the Text Analytics collection;
- The integration of PKPD tools like NONMEM, PsN, and WinBUGS generated new business in advance on the long-term company strategy to go towards clinical drug development;
- Managed team effort to create a standard, and now essential, demonstration slide deck, summarizing on all component collections.
Received 2 Accelrys Excellence Awards in 2009 for exceptional performance, initiative and continuous improvement.
2005-2006
13 months
Computational Chemist
Technologie Servier, Biopharmaceutical research department, Orléans (Dr Ph Vayer)
Defined a global in silico strategy to predict human intestinal absorption, based on three quantitative structure-property relationship models predicting (1) passive absorption, (2) P-Glycoprotein involvement and (3) its impact on drugs.
Created these multivariate data analysis models based on physicochemical (Volsurf approach) and pharmacophoric (Almond approach) 3D descriptors derived from GRID molecular interaction fields. Compiled literature data and advised to conduct assays to fill in missing data.
Conceived a Python-based Intranet application (1) predicting ADME properties including these models as well as other models, (2) operating dissimilarity-based compound selection.
Trained the department, using it as a method to confirm in vitro and in vivo assays.
2005
2 months
Bioinformatician
UMR CNRS 5558, School of Medicine, Lyon 1 University (Pr JP Flandrois)
Created bioinformatics Python-based object-oriented webwares, adapted to routine practice:
PhyID (bacterial and viral phylogenetic identification) and
SequenceColourist* (nucleotidic or peptide sequences colouring).
Trained the hospital users, evaluated the applications with their feedback and wrote manuals.
2004
3 months
Clinical and pharmaceutical fellowship training
Toliara's Province Reference Hospital Centre, Madagascar
Introduced a hospital hygiene improvement program in cooperation with the hospital administration and the medical team.
Clinical fellowship training at psychiatry departement and maternity ward.
2003-2004
9 months
Clinical and pharmaceutical fellowship training
Poissy Saint-Germain-en-Laye Hospital Centre (Pr D Brossard)
Clinical fellowship training in geriatrics: Investigated statistical analysis of prescriptions.
Pharmaceutical fellowship training: Dispensed drugs, reconstituted antineoplastic agent.
2002-2003
6 months
C Developer
Biomathematics laboratory, School of Pharmacy, Paris 5 University (Pr S Bénazeth)
Created a population sampling simulation software, based on Monte-Carlo simulation.
Participated in the development of a complex speciation software.
2000-2001
3 months
PHP MySQL Developer
ViralGames, Incubator of the Telecommunications National School of Paris
Created a PHP/MySQL dynamic statistics graphics rendering engine.
1998-2000
8 months
Steward
Air France, Roissy Charles De Gaulle airport
Steward on the North American, African, Asian and European networks.
Education
2006
Doctor of Pharmacy, with Honours
National competitive examination
Research Thesis: « An application of molecular modelling: the human intestinal absorption »
School of Pharmacy, René Descartes Paris 5 University (Pr S Bénazeth)
Technologie Servier, Biopharmaceutical research department, Orléans (Dr Ph Vayer)
2006
2nd level MSc Degree equivalent « Bioinformatics », with Distinction
Denis Diderot Paris 7 University (Pr C Etchebest)
2005
1st level MSc Degree equivalent « Structural Bioinformatics », with Honours
School of Pharmacy, René Descartes Paris 5 University (Pr S Bénazeth)
2004
1st level MSc Degree equivalent « Biological and medical sciences »
School of Pharmacy, René Descartes Paris 5 University
Computational Skills
Scientific
applications
Data Pipelining
Pipeline Pilot
Molecular modelling
Accelrys Discovery Studio, Tripos SYBYL & SPL, GROMACS, CHARMM, Modeller
Quantitative structure-activity relationships (QSAR)
VolSurf, Almond, GRID, Golpe, MetaSite, ComFa
3D visualization
PyMol, OpenGL, VMD, Jmol, Rasmol, SwissPDBViewer
Bioinformatics
SRS, Muscle, Clustalw, NJPlot, PhyID, Seaview, SequenceColourist*
Computer
sciences
Operating systems
Mac, Linux, Windows
Programming & Scripting
Python, PHP, R, Linux Shell, C, OpenGL
Databases & Web Design
MySQL, PHPMyAdmin, Apache, JavaScript, HTML, CSS, LATEX
Associative Activities & Interests
Volunteer
work
Huma Pharma, association member (1998-2004) and vice-president (1999-2001)
Created an annual hospital hygiene improvement program in Madagascar (since 2002)
Started a weekly program aimed at working with homeless (since 2001)
Founded an annual cultural festival, making public aware of volunteer work (since 2000)
Musical
training
Advanced Musical Studies Diploma in clarinet and in chamber music (DFE)
Bass clarinet, Sopranino, soprano, alto, tenor and bass recorders, Symphonic orchestra
Francis Poulenc music conservatory, Paris 16 & Ménestrel music school, Chantilly 60
Sans dessus de Sons, association president (since 2007)
Takalo-mozika, jazz association founder president (1999-2005)
Planned, budgeted and organized a cultural exchange tour with artists throughout Madagascar.
Performed tours, concerts and events regularly & a weekly jazz jam session with
PavéJazz
First aid
Obtained the first aid training certificate.
References
References available upon request