Stéphane VELLAY, PharmD

+44 774 002 5922
stephane.vellayarobasefree.fr

51A Thornhill square London N1 1BE UK
http://stephane.vellay.free.fr

Summary of qualifications

  • 5 years experience in pharmaceutical and software industries for drug discovery & development
  • Expert in life science: chemistry, biology, drug absorption distribution metabolism and elimination (ADME), imaging, virtual screening
  • Conversant with computational modelling & simulation, scientific programming
  • Lead by example, excellent interpersonal communication skills, promote team work across different disciplines, build trust relationship
  • Native French speaker, fluent in English, intermediate in German

Work Experience

from 2007

Senior Application Scientist
Accelrys, Client Solutions Department EMEA, Cambridge UK (E Vande Water)

Grow usage of Pipeline Pilot (scientific workflow technology) in the scientific community by identifying users' needs and advising or developing appropriate solutions, via various ways:
  • Demonstration: Explaining benefits to users, and developing tailored proof-of-concept, each week in a different scientific environment or company;
  • Training: Leading by example, provided more than a hundred training, with excellent feedback from both new and expert users, about most of the component collections;
  • Support: Became a trusted advisor (inside and outside company) in a variety of Pipeline Pilot component collections (esp. Imaging, Reporting, Text Analytics) and in data visualization;
  • Consulting Services: Engaged in various projects for scientific expertise (e.g. imaging, PKPD, computational chemistry) or interface usability.
Initiated and developed projects recognized and reused by the community or my team:
  • The creation of the Bibliography Platform led to a publication and the wide promotion of the Text Analytics collection;
  • The integration of PKPD tools like NONMEM, PsN, and WinBUGS generated new business in advance on the long-term company strategy to go towards clinical drug development;
  • Managed team effort to create a standard, and now essential, demonstration slide deck, summarizing on all component collections.
Received 2 Accelrys Excellence Awards in 2009 for exceptional performance, initiative and continuous improvement.

2005-2006
13 months

Computational Chemist
Technologie Servier, Biopharmaceutical research department, Orléans (Dr Ph Vayer)

Defined a global in silico strategy to predict human intestinal absorption, based on three quantitative structure-property relationship models predicting (1) passive absorption, (2) P-Glycoprotein involvement and (3) its impact on drugs.
Created these multivariate data analysis models based on physicochemical (Volsurf approach) and pharmacophoric (Almond approach) 3D descriptors derived from GRID molecular interaction fields. Compiled literature data and advised to conduct assays to fill in missing data.
Conceived a Python-based Intranet application (1) predicting ADME properties including these models as well as other models, (2) operating dissimilarity-based compound selection.
Trained the department, using it as a method to confirm in vitro and in vivo assays.

2005
2 months

Bioinformatician
UMR CNRS 5558, School of Medicine, Lyon 1 University (Pr JP Flandrois)

Created bioinformatics Python-based object-oriented webwares, adapted to routine practice: PhyID (bacterial and viral phylogenetic identification) and SequenceColourist* (nucleotidic or peptide sequences colouring).
Trained the hospital users, evaluated the applications with their feedback and wrote manuals.

2004
3 months

Clinical and pharmaceutical fellowship training
Toliara's Province Reference Hospital Centre, Madagascar

Introduced a hospital hygiene improvement program in cooperation with the hospital administration and the medical team.
Clinical fellowship training at psychiatry departement and maternity ward.

2003-2004
9 months

Clinical and pharmaceutical fellowship training
Poissy Saint-Germain-en-Laye Hospital Centre (Pr D Brossard)

Clinical fellowship training in geriatrics: Investigated statistical analysis of prescriptions.
Pharmaceutical fellowship training: Dispensed drugs, reconstituted antineoplastic agent.

2002-2003
6 months

C Developer
Biomathematics laboratory, School of Pharmacy, Paris 5 University (Pr S Bénazeth)

Created a population sampling simulation software, based on Monte-Carlo simulation.
Participated in the development of a complex speciation software.

2000-2001
3 months

PHP MySQL Developer
ViralGames, Incubator of the Telecommunications National School of Paris

Created a PHP/MySQL dynamic statistics graphics rendering engine.

1998-2000
8 months

Steward
Air France, Roissy Charles De Gaulle airport

Steward on the North American, African, Asian and European networks.

Education

2006

Doctor of Pharmacy, with Honours

National competitive examination
Research Thesis: « An application of molecular modelling: the human intestinal absorption »

School of Pharmacy, René Descartes Paris 5 University (Pr S Bénazeth)
Technologie Servier, Biopharmaceutical research department, Orléans (Dr Ph Vayer)

2006

2nd level MSc Degree equivalent « Bioinformatics », with Distinction

Denis Diderot Paris 7 University (Pr C Etchebest)

2005

1st level MSc Degree equivalent « Structural Bioinformatics », with Honours

School of Pharmacy, René Descartes Paris 5 University (Pr S Bénazeth)

2004

1st level MSc Degree equivalent « Biological and medical sciences »

School of Pharmacy, René Descartes Paris 5 University

Computational Skills

Scientific
applications

Data Pipelining

Pipeline Pilot

Molecular modelling

Accelrys Discovery Studio, Tripos SYBYL & SPL, GROMACS, CHARMM, Modeller

Quantitative structure-activity relationships (QSAR)

VolSurf, Almond, GRID, Golpe, MetaSite, ComFa

3D visualization

PyMol, OpenGL, VMD, Jmol, Rasmol, SwissPDBViewer

Bioinformatics

SRS, Muscle, Clustalw, NJPlot, PhyID, Seaview, SequenceColourist*

Computer
sciences

Operating systems

Mac, Linux, Windows

Programming & Scripting

Python, PHP, R, Linux Shell, C, OpenGL

Databases & Web Design

MySQL, PHPMyAdmin, Apache, JavaScript, HTML, CSS, LATEX

Associative Activities & Interests

Volunteer
work

Huma Pharma, association member (1998-2004) and vice-president (1999-2001)

Created an annual hospital hygiene improvement program in Madagascar (since 2002)
Started a weekly program aimed at working with homeless (since 2001)
Founded an annual cultural festival, making public aware of volunteer work (since 2000)

Musical
training

Advanced Musical Studies Diploma in clarinet and in chamber music (DFE)

Bass clarinet, Sopranino, soprano, alto, tenor and bass recorders, Symphonic orchestra

Francis Poulenc music conservatory, Paris 16 & Ménestrel music school, Chantilly 60

Sans dessus de Sons, association president (since 2007)

Coaching the soundpainting ensemble Amalgammes

Takalo-mozika, jazz association founder president (1999-2005)

Planned, budgeted and organized a cultural exchange tour with artists throughout Madagascar.
Performed tours, concerts and events regularly & a weekly jazz jam session with PavéJazz

First aid

Obtained the first aid training certificate.

References

References available upon request